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Applications » Antibiotics » Macrolide antibiotics

Macrolide antibiotics

ALEXYS Azithromycin Analyzer

  • According US and European Pharmacopoeia
  • One Analyzer for different macrolide antibiotics
  • FlexCell with easy exchangeable electrode
  • Reproducible and robust analysis

The macrolides are a group of antibiotics whose activity stems from the presence of a macrolide ring, a large macrocyclic lactone ring to which one or more deoxy sugars may be attached.

The antimicrobial spectrum of macrolides is slightly wider than that of penicillin, and, therefore, macrolides are a common substitute for patients with a penicillin allergy. Azithromycin (Azi) is a semisynthetic macrolide antibiotic. It is effective against a wide variety of bacteria organisms, such as Hemophilus influenzae, Streptococcus pneumoniae, Staphylococcus aureus, and many others. Azithromycin is used to treat bacterial infections such as bronchitis, pneumonia, sexually transmitted diseases (STD) and infections of the ears, lungs, skin, and throat.

Other macrolide antibiotics that can be reproducibly analysed with the ALEXYS Analyzer are Clarithromycin, Erythromycin, Roxithromycin.

Example chromatograms from ‘azithromycin for injection’, section ‘impurities’  (l) and ‘assay’ (r) using HPLC with ECD and UV detection. Peaks are (l): desosaminylazithromycin (1), N-demethylazithromycin (2) and azithromycin (3) and (r): azaerythromycin (1) and azithromycin (2).