Aminoglycosides
ALEXYS analyzer for aminoglycoside antibiotics
- According US and European Pharmacopeia
- One Analyzer for all aminoglycosides
- FlexCell with easy exchangeable electrode
- Reproducible and robust analysis
The Aminoglycoside Analyzer can be used for the analysis of all type of aminoglycosides such as: Amikacin, Framycetin, Gentamicin, Kanamycin, Lincomycin, Netilmicin, Neomycin, Spectinomycin, Streptomycin, Tobramycin, etc.
The system is dedicated to the analysis of these antibiotics in pharmaceutical formulations and bulk products. Aminoglycosides are manufactured by a fermentation process and the main constituents as well as impurities and by-products must be identified and quantified for USP and EP compliance requirements. How to interpret the system suitability requirements and the flexibility in allowable adjustments is in the additional information at the bottom of this page.
The system uses reversed phase chromatography with post column addition of sodium hydroxide for pulsed amperometric detection, except for the Kanamycin/Amikacin, which uses ion exchange chromatography. The supplied FlexCell with its easy exchangeable electrode guarantees for fast and user-friendly operation.
Antibiotics applications
| Title | Version | Size | Download |
|---|---|---|---|
| 217_010 - Neomycin and Framycetin Sulfate in bulk drugs | 14 | 2.84 MB | Download |
| 217_013 - Gentamicin Sulphate in Pharmaceuticals | 15 | 627.36 KB | Download |
| 217_014 - Tobramycin in Pharmaceuticals | 11 | 2.39 MB | Download |
| 217_015 - Amikacin and Kanamycin according USP | 14 | 868.57 KB | Download |
| 217_018 - Spectinomycin in Pharmaceuticals | 12 | 669.50 KB | Download |
| 217_019 - Spectinomycin and Lincomycin | 10 | 966.40 KB | Download |
| 217_030 - Gentamicin EP USP | 07 | 8.43 MB | Download |
| 217_031 - Netilmicin sulphate according EP | 09 | 830.38 KB | Download |
| 217_032 - Tobramycin according EP | 06 | 2.08 MB | Download |
| 217_036 - Streptomycin Sulfate USP | 05 | 799.10 KB | Download |
| 217_040 - Azithromycin according USP | 05 | 1.32 MB | Download |
| 217_041 - Erythromycin ointments according USP | 05 | 935.32 KB | Download |
| 217_042 - Sulfamethoxazole and Trimethoprim | 03 | 714.39 KB | Download |
| 217_043 - Amikacin sulfate according EP | 04 | 1.16 MB | Download |
Pharma - supporting material
| Title | Version | Size | Download |
|---|---|---|---|
| 217_000 Allowable_Compendial_Adjustments_LCGC | 01 | 4.93 MB | Download |
| 217_000 Adjustment to USP Monographs Flexibility and Limitations | 01 | 142.58 KB | Download |
| 217_000 Adjustment the USP Way | 01 | 1.77 MB | Download |