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Epinephrine in anesthesia

Epinephrine in pharma products

Articaine in combination with epinephrine is used as an anesthetic for dental procedures in a number of European countries, US and Canada. Like other local anesthetic drugs, articaine causes a transient and completely reversible state of anesthesia (loss of sensation). Epinephrine is added for its vasoconstrictive effect, it constricts the blood vessels and keeps the anesthetic drug where it is most needed.

The U.S. Pharmacopoeia monograph for Articaine Hydrochloride and Epinephrine injections describes a method for the analysis of the Epinephrine contents and organic impurity analysis. This method is based on HPLC in combination with electrochemical detection in the DC mode on a glassy carbon working electrode.


The USP method is applicable for a few similar substances as well.

  • Articaine hydrochloride and epinehrine injections
  • Lidocaine and epinephrine injection
  • Bupivacaine hydrochloride and Epinephrine injections
  • Prilocaine and epinephrine injection