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How do I know if a substance is EC detectable?

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Applies to

Electrochemical detection


Recommended approach to determine whether a substance is EC active or not:

  1. Literature search for HPLC ECD detection methods, try Google Scholar, RSC, or Research Gate for example.
  2. Look for structural formula if functional groups are EC active (catechol, phenol etc).



If these steps are not successful in answering the question then the EC activity can be determined experimentally:

  1. If a HPLC method is available, a hydrodynamic voltammogram (detector user manual) is constructed.
  2. If no HPLC method is available, a scanning voltammogram is made, as described in the users manual.


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