Newsletters

March 22, 2021

An updated application note has been released featuring the assay for ‘azithromycin for injection’. The method follows the USP 41 monograph using HPLC in combination with UV detection. It is now possible to run both the ECD and UV methods in the USP monographs for azithromycin formulations using the ALEXYS analyzer!

For more details see our website, or click to download the note.

Did you know there is a dark side to a juicy burger or crispy bacon? No, this is not about being a vegetarian or other dietary restrictions. This is literally about the darkened side of grilled or roasted meat. About the chemistry that takes place with nitrate, nitrite, proteins and other amines forming nitrosamines. How well-prepared meat can have carcinogenic side effects, and why concentrations of nitrate and nitrite is of a concern.

In a new Application Note we describe the analysis of nitrate and nitrite using HPLC with UV detection. For more details see our website, or click to download the note.

A new application note has been released about the analysis of sulfamethoxazole and trimethoprim. The method is using HPLC with electrochemical detection. A multistep potential has been applied for stable and reproducible working conditions.

For more details see our website, or click to download the note.

A new application note has been released for the analysis of carbohydrates in food, dietary supplements, pet food and animal feeds. We used the method as published by AOAC. The analysis is based on gradient separation on a High-Performance Anion-Exchange column followed by pulsed amperometric detection using a 4-step potential waveform.

For more details on carbohydrate analysis see our website.
Or click to download the new AOAC note.

Recently we introduced a few new Remote Assisted Services. What we learned so far, is that the participating customers highly appreciate the remote sessions. For us this is an unexpected side effect, which encouraged us to develop a few more.

By doing the actual work, users are more involved in the session thus gaining a deeper understanding of the instruments.

More details and downloads are on our website.

November 25, 2020

Our improved ALEXYS Carbohydrate Analyzer has exciting new features, such as a solvent tray to facilitate carbon dioxide free solvents, and extended temperature stability at ambient. We apply flow cells with solid gold working electrode to guarantee stable performance, high sensitivity and stability!

YOUR WORKHORSE,
within 1 hour completely stabilized, ready for injection!!

For more details and applications see our website, or contact us.

September 25, 2020

Clarity 8 has a new look and feel, and the number of new device drivers is continuously growing. New features for Antec:

• Multi-step pulse mode (mPAD) for Elite
• Programmable solvent selector for P6.1pump
• AS 110 driver with User Defined Programs (AS FW 1.31)
• Comes with installer for ALEXYS Analyzers
• Website tutorials from Antec and DataApex

For more details see our website.

We are happy to announce that a new Antec ECD driver has been released for OL Chemstation™ CDS from Agilent.

We now have drivers for:

• Chemstation™ (Agilent)
• OpenLab™ (Agilent)
• Chromeleon™ (Thermo Fisher Scientific)
• Clarity™ (Data Apex)
• Dialogue Elite™ (Antec Scientific)

Read more on our website….

August 5, 2020

Have a look at our ‘playlist’ of work that was done with our ROXY Reactors for EC/MS. The list includes the compounds, type of reactor/electrode, and mode of analysis. Each publication has a dynamic internet link for convenient retrieval.

A good literature reference describing a new approach may trigger new ideas. Feel free to download & share!

Over the past year we have received questions what flow cell to use for the analysis of carbohydrates. Method of analysis is HPLC with Pulsed Amperometric Detection (HPAEC-PAD) using a flow cell with gold electrode and HyREF. Both FlexCell and SenCell will do, here is what we think how to choose:

FlexCell: our first choice for 3-step pulsed amperometric detection. It has a high pH inert HyREF reference electrode and an exchangeable working electrode. This is a particularly useful feature to cope with the normal wear of the gold electrode. Taking out the electrode to polish or replace is easy.

SenCell: is recommended in case a 4-step pulse can be used with minimum wear of the gold electrode. It also has an inert HyREF reference electrode, and in most applications it has a bit better signal-to-noise ratio. Therefore, in most recent application notes we now use the SenCell.

Histamine is one of those substances with a multitude of functions in the body. Probably the most annoying is its capability to trigger an immune response followed by itching or hay fever and such. As a neurotransmitter it plays a role to control the sleep-wake cycle.

It also plays a role in a totally different field, in fish products. Histamine levels rise with insufficient cooling or poor hygiene. It says something about freshness and fish quality for consumption.

Recently, we published a method for analysis of Histamine using our in-needle OPA derivatization – click to download.

Did you know that behavior can be affected by the food we eat? In agriculture this has been known for quite some time. By adding certain amino acids to animal food it has been shown that animals have less stress and aggression.

Recently, we published a method for analysis of LNAAs – Large Neutral Amino Acids including  Tryptophan, Tyrosine, and Phenylalanine – that play a key role in this. Click to download.

July 14, 2020

Isn’t it amazing how studying the brain neurotransmitters of the tiny fruit fly – Drosophila Melanogaster – helps to understand how things work in mammals? Clearly, size does not matter … in this case!

Recently, we published a method for analysis of Octopamine, Tyramine, Tyrosine and Tryptophan – click to download.

June 16, 2020

We have recently developed a new FlexCell with Stainless Steel Auxiliary electrode especially for USP and EP methods. It combines the flexibility of an exchangeable gold working electrode with the USP/EP requirement for stainless steel AUX. The maintenance free & pH inert HyREF works very well for aminoglycosides or other carbo’s that are analyzed under alkaline conditions.

• 102.4325EP  –  FlexCell Au HyREF, SS AUX

Below the new FlexCell (left). For more details see our web page.

June 16, 2020

We have some background information about the Antec ECD driver for Chromeleon™ CDS from Thermo Fisher Scientific and the Chromeleon “Class 3” license requirement.

Currently, several flavors of Chromeleon are available. First there is a choice between Workstation (standalone PC) or Enterprise (multi-PC Network) license. Then there are Class 1, 2 and 3 licenses:

• Class 1: all Thermo Fisher Scientific instruments
• Class 2: third party GC’s
• Class 3: third  party LC’s

A Class 3 license automatically covers all Class 1 devices as well. Check what version of Chromeleon is being used. In case of class 1, contact Thermo Fisher Scientific as it should be upgraded to Class 3 to be able to work with an Antec ECD.

For more details and driver downloads see our web page.

June 16, 2020

We created two checklists for Antec users to keep track of the daily maintenance and checks in HPLC/ECD. Particularly useful in troubleshooting are the daily entries for key parameters such as I-cell, pressure reading and the system suitability result.

We have a checklist for ALEXYS Analyzers, and one for 3rd party HPLC with Antec ECD which has less detail on pump and autosampler.

• 180_0029_01 – ALEXYS operator checklist
• 171_0029_01 – HPLC/ECD operator checklist

For downloading the checklists see our web page.