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Epinephrine in anaesthesia

drug delivery

ALEXYS Analyzer with DECADE Elite


A number of aneastetics such as bupivacaine, lidocaine, prilocaine and articaine use epinephrine as additive. It is a vasoconstrictor to retain the anestetic effect. Articaine in combination with epinephrine is used as an anesthetic for dental procedures in a number of European countries, US and Canada. Like other local anesthetic drugs, articaine causes a transient and completely reversible state of anesthesia (loss of sensation). The U.S. Pharmacopoeia monograph for Articaine Hydrochloride and Epinephrine injections describes a method for the analysis of the Epinephrine contents and organic impurity analysis. The ALEXYS Analyzer for Epinephrine in anesthetics is in compliance with all USP and EP requirements.

Application Notes

System configuration

For the analysis of einephrine we selected the SenCell with sb reference electrode. This cell not only has an excellent reproducibility but also the best possible detection sensitivity. The ALEXYS system comprises the following parts:

ALEXYS Analyzers

  • AS 110 autosampler, cool
  • LC 110S HPLC pump
  • OR 110 organiser rack
  • Clarity data acquisition software
  • DECADE Elite electrochemical detector
  • SenCell with GC WE, sb REF


Part no Description
180.0055C ALEXYS Analyzer for Epinephrine
250.1070B Phenomenex Luna 5μ C8(2), 250 x 4.6 mm column