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Synthesis of mg quantities

SynthesisCell™ - batch reactor for scale-up

The SynthesisCell is a typical batch reactor (80 mL) designed to generate mg quantities of compounds that are difficult or impossible to synthesize using traditional techniques, e.g., wet chemistry, catalytic, or enzymatic approaches. It is the ideal cell for the rapid synthesis of (drug) metabolites or biotransformation products of xenobiotics, including degradants (drug stability).

The SynthesisCell is available with the ROXY EC System and offers a wide variety of electrode materials to achieve optimal yield and compound selectivity.

Application Notes

Product Flyers

26116769 - Preparing the key metabolite of Z-ligustilide in vivo by a specific electrochemical reaction
F Duan, W Xu, J Liu, Z Jia, K Chen; Journal of Separation Science (2018) 41: 2799-2807

26116770 - Prediction of biotransformation products of the fungicide fluopyram by electrochemistry coupled online to liquid chromatography-mass spectrometry and comparison …
TF Mekonnen, U Panne, M Koch ; Analytical and Bioanalytical Chemistry (2018) 410: 2607-2617

26116771 - Electrochemical simulation of triclosan metabolism and toxicological evaluation
L Zhu, Y Shao, H Xiao, B Santiago-Schübel; Science of the Total Environment (2018) 622–623: 1193-1201

26116772 - Electrochemistry coupled online to liquid chromatography-mass spectrometry for fast simulation of biotransformation reactions of the insecticide chlorpyrifos
U Panne, M Koch; Anal Bioanal Chem (2017) 409:3359–3368

26116773 - Electrochemical oxidation of fluoroquinolone antibiotics: Mechanism, residual antibacterial activity and toxicity change
L Zhu, B Santiago-Schübel, H Xiao, H Hollert; Water Research (2016) 102: 52-62

26116774 - KAE609 (Cipargamin), a new spiroindolone agent for the treatment of malaria: Evaluation of the Absorption, Distribution, Metabolism and Excretion of a single oral 300 …
SEW Huskey, C Zhu, A Fredenhagen, J Kuhnol; Drug Metabolism and Disposition (2016) DOI: https://doi.org/10.1124/dmd.115.069187

26116775 - … pharmaceutical oxidation products using electrochemistry: a systematic study of N-dealkylation reactions of fesoterodine using a commercially available synthesis cell
S Torres, R Brown, R Szucs, JM Hawkins; Org. Process Res. Dev. (2015) 19: 1596-1603

26116776 - An efficient laboratory workflow for environmental risk assessment of organic chemicals
L Zhu, B Santiago-Schübel, H Xiao, B Thiele, Z Zhu; Chemosphere (2015) 131: 34-40

00216-013-7021 - Generation of statin drug metabolites through electrochemical and enzymatic oxidations
Smriti Khera, Na Hu; Analytical and Bioanalytical Chemistry, July 2013, Volume 405, Issue 18, pp 6009–601