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Applications » Antibiotics » Aminoglycosides

Aminoglycosides

ALEXYS analyzer for aminoglycoside antibiotics

  • According US and European Pharmacopeia
  • One Analyzer for all aminoglycosides
  • FlexCell with easy exchangeable electrode
  • Reproducible and robust analysis

The Aminoglycoside Analyzer can be used for the analysis of all type of aminoglycosides such as: Amikacin, Framycetin, Gentamicin, Kanamycin, Lincomycin, Netilmicin, Neomycin, Spectinomycin, Streptomycin, Tobramycin, etc.

The system is dedicated to the analysis of these antibiotics in pharmaceutical formulations and bulk products. Aminoglycosides are manufactured by a fermentation process and the main constituents as well as impurities and by-products must be identified and quantified for USP and EP compliance requirements. How to interpret the system suitability requirements and the flexibility in allowable adjustments is in the additional information at the bottom of this page.

The system uses reversed phase chromatography with post column addition of sodium hydroxide for pulsed amperometric detection, except for the Kanamycin/Amikacin, which uses ion exchange chromatography. The supplied FlexCell with its easy exchangeable electrode guarantees for fast and user-friendly operation.

Application notes

 

Rev
Name
Size
Download
217_010_15
Neomycin and Framycetin Sulfate in bulk drugs
3.00 MB
217_013_17
Gentamicin Sulphate in Pharmaceuticals
0.62 MB
217_014_12
Tobramycin in Pharmaceuticals
2.55 MB
217_015_15
Amikacin and Kanamycin according USP
0.69 MB
217_017_15
Azithromycin_Erythromycin_Macrolide_Antibiotics
1.02 MB
217_018_13
Spectinomycin in Pharmaceuticals
3.86 MB
217_019_11
Spectinomycin and Lincomycin
0.86 MB
217_030_08
Gentamicin EP USP
8.53 MB
217_031_11
Netilmicin sulphate according EP
0.85 MB
217_032_07
Tobramycin according EP
2.32 MB
217_036_06
Streptomycin Sulfate USP
0.68 MB
217_040_06
Azithromycin according USP
1.25 MB
217_041_06
Erythromycin ointments according USP
0.95 MB
217_042_04
Sulfamethoxazole and Trimethoprim
0.72 MB
217_043_06
Amikacin sulfate according EP
1.17 MB

EP/USP adjustments

 

Rev
Name
Size
Download
217_000_01
Adjustment the USP Way
1.77 MB
217_000_01
Adjustment to USP Monographs Flexibility and Limitations
0.14 MB
217_000_01
Allowable_Compendial_Adjustments_LCGC
4.93 MB