The Aminoglycoside Analyzer can be used for the analysis of all type of aminoglycosides such as: Amikacin, Framycetin, Gentamicin, Kanamycin, Lincomycin, Neomycin, Spectinomycin, Streptomycin, Tobramycin, etc.
The system is dedicated to the analysis of these antibiotics in pharmaceutical formulations and bulk products. Aminoglycosides are manufactured by a fermentation process and the main constituents as well as impurities and by-products must be identified and quantified to fulfil USP and EP requirements.
The system uses reversed phase chromatography with post column addition of sodium hydroxide for pulsed amperometric detection, except for the Kanamycin/Amikacin, which uses an ion exchange column. The supplied FlexCell with its easy exchangeable electrode guarantees for fast maintenance and operation. All parts and accessories are supplied with the Analyzer to assure reproducible and robust analysis.
For the analysis of aminoglycosides we selected the Flexcell electrochemical cell. This cell has an exchangeable working electrode which is particularly useful in pulsed electrochemical detection. The electrode material tends to vanish over the years, in the process of pulsed amperometric detection. Exchanging an electrode disc only takes a few minutes. The HyREF is completely maintenance free even at pH 13 which is required for pulsed amperometric detection! The ALEXYS system comprises the following parts:
Aminoglycosides 180.0050/56/59 require post-column addition of sodium hydroxide for detection. System 180.0058C is based on ion exchange chromatography at high pH (no post column addition). In addition to the first mentioned list this system includes Helium-proof solvent bottles.
|180.0050C||ALEXYS Aminoglycosides Analyzer|
|180.0056C||ALEXYS Gentamicin Analyzer|
|180.0058C||ALEXYS Kanamycin/Amikacin Analyzer|
|180.0059C||ALEXYS Spectinomycin/Lincomycin Analyzer|