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Monoamines and metabolites

ALEXYS Neurotransmitter Analyzer

ALEXYS Neurotransmitter Analyzer: UHPLC for all neurotransmitters

 

 

The ALEXYS Neurotransmitter Analyzer utilizes the extraordinary separation power of sub-2 μm packed columns. Plate numbers, retention times and detection sensitivity have been pushed to their limits.
The system is based on a single channel configuration with kits for common neutronsmitters: noradrenaline, dopamine, serotonin and metabolites, GABA & glutamate or acetylcholine & choline etc. The system can be extended with several options and kits for any combination of neurotransmitters.

On-line Microdialysis

Applying an external electric valve instead of an autosampler makes the system suitable for sampling directly from the microdialysis flow. On-line microdialysis offers the unique possibility to obtain real time feedback on neurochemical changes. The extremely short run time in UHPLC facilitates a high temporal resolution.


Application Notes

Application Notebook

  • 213_070_05 - Application Notebook Neurotransmitter

Posters

  • 221_227_02 - ALEXYS Neurotransmitter analyzer SFN2016
  • 221_119_01 - Recent Developments in Neurotransmitter Analysis Neuroscience2014_04
  • 221_118_01 - Online fast analysis of dopamine and serotonin for high time resolution Neuroscience2014
  • 221_093_01 - Neurotransmitter Analysis Dopamine2013
  • 221_082_02 - New ALEXYS neurotransmitter analyzer SfN 2012
  • 221_081_01 - New Flow cell for Neurotransmitter Analysis SfN 2012
  • 221_080_01 - Neurotransmitter Analysis MMol2012
  • 221_033_01 - Neurotransmitter Analysis of Microdialysates with ALEXYS

System configuration

The Neurotransmitter Analyzer (pn 180.0091U) has several complementary kits for specific applications. Columns are all 1 mm ID and where possible the sub-2 μm packing is applied. All critical parts have an improved pressure rating, not only the LC 110S pump but also the autosampler, the pulsedampener and all connecting tubing and fittings. For GABA and Glutamate analysis an additional pump is applied to eliminate late eluting peaks with a step gradient.

The ALEXYS system comprises the following parts:

  • AS 110 autosampler, cool, micro, UHPLC
  • LC 110S HPLC pump
  • OR 110 organiser rack, UHPLC
  • Clarity data acquisition software
  • DECADE Elite electrochemical detector, SCC

The column and cell are in the complementary kit.

Monoamines: ALEXYS Analyzers

Part no Description
180.0091U ALEXYS Neurotransmitter Analyzer 
180.0502 ALEXYS Monoamines kit

Acetylcholine and Choline:

Part no Description
180.0091U ALEXYS Neurotransmitter Analyzer
180.0506 ALEXYS Acetylcholine kit

 GABA and Glutamate:

ALEXYS Analyzers

Part no Description
180.0091U ALEXYS Neurotransmitter Analyzer
180.0504 ALEXYS GABA/Glu kit
180.0602 LC step-gradient upgrade