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Monoamines and metabolites

ALEXYS Neurotransmitter Analyzer

ALEXYS Neurotransmitter Analyzer: UHPLC for all neurotransmitters



The ALEXYS Neurotransmitter Analyzer utilizes the extraordinary separation power of sub-2 μm packed columns. Plate numbers, retention times and detection sensitivity have been pushed to their limits.
The system is based on a single channel configuration with kits for common neutronsmitters: noradrenaline, dopamine, serotonin and metabolites, GABA & glutamate or acetylcholine & choline etc. The system can be extended with several options and kits for any combination of neurotransmitters.

On-line Microdialysis

Applying an external electric valve instead of an autosampler makes the system suitable for sampling directly from the microdialysis flow. On-line microdialysis offers the unique possibility to obtain real time feedback on neurochemical changes. The extremely short run time in UHPLC facilitates a high temporal resolution.

Application Notes

Application Notebook

  • 213_070_06 - Application Notebook Neurotransmitter


  • 221_081_01 - New Flow cell for Neurotransmitter Analysis SfN 2012
  • 221_237_01 - GABA & Glutamate, Histamine, LNAAs and other Amino Acids
  • 221_238_01 - Fast and sensitive analysis with the ALEXYS Neurotransmitter Analyzer
  • 221_239_01 - Fast analysis for high time resolution

System configuration

The Neurotransmitter Analyzer (pn 180.0091U) has several complementary kits for specific applications. Columns are all 1 mm ID and where possible the sub-2 μm packing is applied. All critical parts have an improved pressure rating, not only the pump but also the autosampler, the pulsedampener and all connecting tubing and fittings. For GABA and Glutamate analysis an additional pump is applied to eliminate late eluting peaks with a step gradient.

The ALEXYS system comprises the following parts:

  • AS 110 autosampler, cool, micro, UHPLC
  • P6.1L HPLC pump
  • Clarity data acquisition software
  • DECADE Elite electrochemical detector, SCC

The column and cell are in the complementary kit.

ALEXYS Analyzers  ALEXYS system


Part no Description
180.0091W ALEXYS Neurotransmitter Analyzer 
191.0055UL AS 110 UHPLC cool 6p, LAN
180.0502 ALEXYS Monoamines kit

Acetylcholine and Choline:

Part no Description
180.0091W ALEXYS Neurotransmitter Analyzer
191.0055UL AS 110 UHPLC cool 6p, LAN
180.0506 ALEXYS Acetylcholine kit

 GABA and Glutamate:

Part no Description
180.0091W ALEXYS Neurotransmitter Analyzer
191.0055UL AS 110 UHPLC cool 6p, LAN
180.0602 LC step-gradient upgrade
180.0504 ALEXYS GABA/Glu kit