Using Electrochemistry (EC) as a reaction technique before the MS allows the analyst to mimic natures’ REDOX reactions in almost any analytical field. Many chemical and catalytic reactions (wet chemistry, Fenton, etc.) can be mimicked in a controlled manner in the electrochemical cell simply by applying a voltage potential. A large number of biochemical reactions such as enzymatic , micorbial, aquatic, photolytic, etc, can be simulated without biological interferences (e.g. cell matrix, plasma, urine, soil, etc.) and the generated REDOX products can be easily detected by MS, making EC/MS a real biomimetic tool with substantial cost and time savings compared to in-vivo or in–vitro techniques.