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ROXY Potentiostat


ROXY™ Potentiostat controls REDOX reactions



The ROXY Potentiostat is recognised as one of the most powerful instruments for controlled REDOX reactions up-front Mass Spectrometric detection [1]. It fits with any MS and can be controlled easily via a contact closure.

The range of applications has grown from pharma applications such as drug metabolism, purposeful degradation and stability testing to other areas such as environmental degradation Lipidomics, Genomics, Foodomics, etc., including the synthesis of mg quantities of REDOX products.
The ROXY Potentiostat generates the metabolites of drugs or xenobiotics, similar to those generated during in vivo metabolic processes, but in a significantly shorter period of time (seconds vs. days or weeks) without any interfering components (no isolation steps required). In proteomics ROXY has become a powerful tool for the reduction of the disulfide bonds in proteins/peptides resulting in increased sequence coverage and easier assessment of disufide bonds in top-down and bottom-up approaches, including HDX/MS. 

The ROXY Potentiostat is based on state-of-the-art electronics with a large voltage range of ± 4.9 V, current up to 20 mA and a push button electrode regeneration program. Operational parameters and external equipment can be controlled through programmable timed events via Antec’s Dialogue software.

Two in One!
The ROXY Potentiostat is available with a large variety of electrochemical reaction cells, e.g., ChipCell, ReactorCell, µ-PrepCell 2.0, SyntehsisCell, etc., and has the capability of controlling two cells independently. This is ideal for simultaneous use of different working electrodes or potentials (parallel mode) or multiple stage oxidation/reduction of target compounds (serial mode). The ROXY Potentiostat comes with a high precision oven for optimal conversion kinetics and reproducibility (ambient up to 45°C).


[1] Awarded as the most innovative product at Analytica 2010, Munich, Germany

Product Flyers



  • 221_070_01 - Online EC MS A Powerful Tool for Fast Prediction of Phase I and II Drug Metabolism
  • 221_076_01 - Expanding Role of Electrochemistry Mass Spectrometry in Life Sciences
  • 221_077_01 - Novel method for efficient reduction of disulfide bonds in peptides and proteins prior MS detection
  • 221_078_01 - Identification of electrochemically synthesized metabolites
  • 221_079_01 - Insights into Nucleic Acids Oxidation by ElectrochemistryLiquid ChromatographyMass Spectrometry
  • 221_090_01 - Degradation of Xenobiotics and Binding to Organic Matter by OnLine EC MS
  • 221_105_01 - Controlled Reduction of Disulfide Bonds in Biopharmaceuticals Using an Electrochemical Reactor Cell online with LCMS Rolduc 2014
  • 221_106_01 - ElectrochemistryMS a Powerful Tool in Drug Metabolism Rolduc 2014
  • 221_107_01 - ElectrochemistryMS a Powerful Tool in Drug Metabolism ASMS 2014
  • 221_108_01 - Controlled Reduction of Disulfide Bonds in Proteins and Peptides Using an Electrochemical Reactor Cell in online LCECMS ASMS 2014
  • 221_115_01 - Controlled Reduction of Disulfide Bonds in Biopharmaceuticals ElCheMS2015
  • 221_116_01 - Enhanced Pharmaceutical Stability ElCheMS2015
  • 221_117_01 - Mimicking Drug Metabolism ElCheMS2015
  • 221_118_01 - Electrochem Reduction of Disulfide Bonds ASMS2015
  • 221_120_01 - ECHDX for the Analysis of Protein Therapeutics HOS2015
  • 221_226_01 - The Application of ElectrochemistryMS to Pharmaceutical Stability Testing and Degradant Synthesis
  • 221_243_01 - New EC cell for superior reduction of protein disulfide bonds
  • 221_246_01 - Triclosan environmental degradation
  • 221_247_01 - Electrochemical Simulation of Phase I Metabolism of Three Novel Cardiovascular Drugs


Part no Description
210.0050A ROXY dual channel Potentiostat, high current version, required for optimal use of SynthesisCell™
210.0060A ROXY 4 channel Potentiostat

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S. Torres et al.; J. Pharm. Biomedical Analysis 131 (2016) 71-79

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D Weber, Z Ni, D Vetter, R Hoffmann, M Fedorova; Eur. J. Lipid Sci. Technol. 2016, 118, 325-331

201500219 - Generation of oxysterols formed by free radicals and enzymes by electrochemical oxidation
G Lizard; Eur. J. Lipid Sci. Technol. 2016, 118, 135-136

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Mysling S, Salbo R, Ploug M, Jørgensen TJ.; Anal Chem. 2013 Nov 19. [Epub ahead of print]

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Kraj A, Brouwer HJ, Reinhoud N, Chervet JP.; Anal Bioanal Chem. 2013 Sep 29. [Epub ahead of print]

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Nicolardi S, Giera M, Kooijman P, Kraj A, Chervet JP, Deelder AM, van der Burgt YE.; J Am Soc Mass Spectrom. 2013 Sep 10. [Epub ahead of print]

23812883 - EC-SPE-stripline-NMR analysis of reactive products: a feasibility study.
Falck D, Oosthoek-de Vries AJ, Kolkman A, Lingeman H, Honing M, Wijmenga SS, Kentgens AP, Niessen WM.; Anal Bioanal Chem. 2013 Aug;405(21):6711-20. doi: 10.1007/s00216-013-7158-9. Epub 2013 Jun 30.

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Liu P, Lu M, Zheng Q, Zhang Y, Dewald HD, Chen H.; Analyst. 2013 Oct 7;138(19):5519-39. doi: 10.1039/c3an00709j.

23763302 - Boron-doped diamond electrodes for the electrochemical oxidation and cleavage of peptides.
Roeser J, Alting NF, Permentier HP, Bruins AP, Bischoff R.; Anal Chem. 2013 Jul 16;85(14):6626-32. doi: 10.1021/ac303795c. Epub 2013 Jun 25.

22772139 - Ascorbic acid for homogenous redox buffering in electrospray ionization-mass spectrometry.
Plattner S, Erb R, Chervet JP, Oberacher H.; Anal Bioanal Chem. 2012 Sep;404(5):1571-9. doi: 10.1007/s00216-012-6196-z. Epub 2012 Jul 8.

23352827 - Influence of cimetidine and its metabolites on Cisplatin--investigation of adduct formation by means of electrochemistry/liquid chromatography/electrospray mass spectrometry.
Brauckmann C, Faber H, Lanvers-Kaminsky C, Sperling M, Karst U.; J Chromatogr A. 2013 Mar 1;1279:49-57. doi: 10.1016/j.chroma.2012.12.069. Epub 2013 Jan 10.

23286982 - In chemico evaluation of skin metabolism: Investigation of eugenol and isoeugenol by electrochemistry coupled to liquid chromatography and mass spectrometry.
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Chen L, Hofmann D, Klumpp E, Xiang X, Chen Y, Küppers S.; Chemosphere. 2012 Nov;89(11):1376-83. doi: 10.1016/j.chemosphere.2012.05.105. Epub 2012 Jul 21.

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22592989 - Electrochemistry/mass spectrometry as a tool in the investigation of the potent skin sensitizer p-phenylenediamine and its reactivity toward nucleophiles.
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Jahn S, Faber H, Zazzeroni R, Karst U.; Rapid Commun Mass Spectrom. 2012 Jun 30;26(12):1415-25. doi: 10.1002/rcm.6247.

22525874 - Identification and quantification of potential metabolites of Gd-based contrast agents by electrochemistry/separations/mass spectrometry.
Telgmann L, Faber H, Jahn S, Melles D, Simon H, Sperling M, Karst U.; J Chromatogr A. 2012 Jun 1;1240:147-55. doi: 10.1016/j.chroma.2012.03.088. Epub 2012 Apr 3.

22448817 - Electrochemistry-assisted top-down characterization of disulfide-containing proteins.
Zhang Y, Cui W, Zhang H, Dewald HD, Chen H.; Anal Chem. 2012 Apr 17;84(8):3838-42. doi: 10.1021/ac300106y. Epub 2012 Apr 4.

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Erb R, Plattner S, Pitterl F, Brouwer HJ, Oberacher H.; Electrophoresis. 2012 Feb;33(4):614-21. doi: 10.1002/elps.201100406.

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Lu M, Wolff C, Cui W, Chen H.; Anal Bioanal Chem. 2012 Apr;403(2):355-65. doi: 10.1007/s00216-011-5679-7. Epub 2012 Jan 12.

22227746 - Electrochemical oxidation and protein adduct formation of aniline: a liquid chromatography/mass spectrometry study.
Melles D, Vielhaber T, Baumann A, Zazzeroni R, Karst U.; Anal Bioanal Chem. 2012 Apr;403(2):377-84. doi: 10.1007/s00216-011-5673-0. Epub 2012 Jan 8.

22227812 - On-line electrochemistry-bioaffinity screening with parallel HR-LC-MS for the generation and characterization of modified p38Î? kinase inhibitors.
Falck D, de Vlieger JS, Giera M, Honing M, Irth H, Niessen WM, Kool J.; Anal Bioanal Chem. 2012 Apr;403(2):367-75. doi: 10.1007/s00216-011-5663-2. Epub 2012 Jan 8.

22227826 - Simulation of the oxidative metabolism of diclofenac by electrochemistry/(liquid chromatography/)mass spectrometry.
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21359310 - Coupling of liquid chromatography with mass spectrometry by desorption electrospray ionization (DESI).
Zhang Y, Yuan Z, Dewald HD, Chen H.; Chem Commun (Camb). 2011 Apr 14;47(14):4171-3. doi: 10.1039/c0cc05736c. Epub 2011 Feb 28.

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20393841 - Electrochemical simulation of oxidation processes involving nucleic acids monitored with electrospray ionization-mass spectrometry.
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Thesis - Electrochemical Oxidation and Cleavage of Peptides in Bioanalysis, Mechanistic Aspects & Method Development Dissertation
J. Roeser; Thesis

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U Panne, M Koch; Anal Bioanal Chem (2017) 409:3359–3368

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26116775 - … pharmaceutical oxidation products using electrochemistry: a systematic study of N-dealkylation reactions of fesoterodine using a commercially available synthesis cell
S Torres, R Brown, R Szucs, JM Hawkins; Org. Process Res. Dev. (2015) 19: 1596-1603

26116776 - An efficient laboratory workflow for environmental risk assessment of organic chemicals
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Smriti Khera, Na Hu; Analytical and Bioanalytical Chemistry, July 2013, Volume 405, Issue 18, pp 6009–601

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