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Can I use an USB to RS232 convertor ?
Applies to Control of devices with Dialogue or Clarity software. Summary New computers not always have RS232 or serial com ports available. An USB to serial port convertor, or a PCI card with serial port is an alternative. Remedy We advise the following combinations: Clarity software: only u...


DECADE II sensor board dip switches
Applies to DECADE II and ROXY Summary Sensorboard identifiers are set using dipswitches.   board dip switches   1 2 3 4  1  on on on  on  2  on off on on  3  off  off  on  on  4 &nb...


Dummy cell test
Applies to   Electrochemical detector Summary The dummy cell test can be used to check the detector electronic circuit and stability performance of the baseline (and oven temperature). The dummy cell consists of a resistor and a capacitor, simulating the function of a real flow cell, but wi...


Gentamicin analysis: high cell current and no peaks
Applies to Gentamycin application Summary Background current rises from a few µA up to 100 µA or more. Analysis of Gentamicin is not possible. Cause Wrong quality THF. The mobile phase is made in accordance with EP. The THF must contain a so called stabilizer to avoid polymerisation...


How do I prepare for an installation or service call?
Applies to Installation of detector, ALEXYS, and ROXY Summary For successful installation visit a couple of things need to be taken care of prior to the visit. Comments Depending on the application or the device there is a 'requirements' document which contains all details on parts and chemical...


How to use Ti based electrodes for disulfide reduction
Applies to ROXY Reactor with Ti based working electrode (WE) for disulfide bond reduction Summary Instruction how to use the Ti based electrode for reduction of disulfide bonds. Comments A numbers of things need to be taken into account for successful operation with the u-PrepCell with Ti based...


I do not get much reaction products
Applies to ROXY, ReactorCell, µ-PrepCell, SynthesisCell Summary The yield of reaction products is very low, or nothing is found in the MS spectra. Cause Possible causes can be related to equipment or measurement conditions. Equipment related: Cell cable with capacitor ...


I hear a strange squeaky noise
Applies to ALEXYS system Summary A number of mechanical parts can make a - usually faint - noise, which is normal. Due to wear and tear the noise sometimes increases. Cause Several parts produce noise: Degasser: vacuum pump LC 100 pump: piston, seals or motor AS 100: syringe spindl...


What steps should I take to switch off my system correctly?
Applies to ALEXYS, ROXY, DECADE II detector Summary There are a couple of steps to take to switch off a system for a longer period of time. Shutting down is not different from most other HPLC systems. Switch off the cell first. Check the column(s) documentation for the appropriate storage liquid,...


When injecting, no sample is introduced
Applies to ALEXYS or ROXY LC system, AS 100/110 autosampler Summary No or too small signal/front peaks visible in chromatogram. Cause Blockage of AS 100/110 flow path or leakage in the injection valve. Diagnosis and Remedy Follow the trouble-shoot instructions in the flow diagram be...