Betadex Sulfobutyl Ether Sodium
ALEXYS Analyzer with DECADE Elite
- Flexcell with exchangeable electrode
- Reproducible analysis of product impurities
- In accordance with Pharmacopeia methods
- New notes (2014) following USP/EP to the letter
Betadex Sulfobutyl Ether Sodium (BSES) is a cyclodextrin that is used as a drug delivery solution. In an USP monograph the purity analysis requirements of this substance is described. The ALEXYS Analyzer for BSES meets these requirements. The system uses HPLC with an anion exchange column and a DECADE Elite for Pulsed Amperometric Detection (PAD). In our application note the method performance is demonstrated for the (im)purity analysis of sulfobutyl ether β-cyclodextrin in bulk material.
Articaine, Ephinephrine, Heparin, Ethylene glycol and others
See Application Notes
Application Notes
- 217_037_04 - Betadex Sulfobutyl Ether Sodium
- 217_035_04 - Epinephrine injections according USP
- 217_033_04 - Heparin according USP
- 217_039_02 - Ethylene glycol in Hydroxyethyl Starch EP
- 217_025_04 - Compilation of Pharmaceutical Application
System configuration
For the analysis of Beta-Cyclodextrin we selected a Flexcell with gold working electrode. This cell has an exchangeable working electrode which is particularly useful in pulsed electrochemical detection. The electrode material tends to vanish over the years, in the process. Exchanging an electrode disc only takes a few minutes. The HyREF is completely maintenance free even at pH 13! The ALEXYS system comprises the following parts:
- AS 110 autosampler, cool
- P6.1L HPLC pump (2)
- Clarity data acquisition software
- DECADE Elite electrochemical detector
- Flexcell with Au WE, HyREF
This system includes Helium-proof solvent bottles.
| Part no | Description |
| 180.0055W | ALEXYS HPAEC-PAD Analyzer, HP gradient |
| 250.1086 |
IonPac AG11 guard column, 50 x 4.0 mm ID |
| 250.1087 | IonPac AS11 analytical column, 250 x 4.0 mm ID |