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Betadex Sulfobutyl Ether Sodium

drug delivery

ALEXYS Analyzer with DECADE Elite

 

Betadex Sulfobutyl Ether Sodium (BSES) is a cyclodextrin that is used as a drug delivery solution. In an USP monograph the purity analysis requirements of this substance is described. The ALEXYS Analyzer for BSES meets these requirements. The system uses HPLC with an anion exchange column and a DECADE Elite for Pulsed Amperometric Detection (PAD). In our application note the method performance is demonstrated for the (im)purity analysis of sulfobutyl ether β-cyclodextrin in bulk material.

Articaine, Ephinephrine, Heparin, Ethylene glycol and others

See Application Notes


Application Notes

  • 217_037_01 - Betadex Sulfobutyl Ether Sodium
  • 217_035_02 - Articaine Epinephrine according to USP
  • 217_039_02 - Ethylene glycol in Hydroxyethyl Starch
  • 217_025_03 - Compilation of Pharmaceutical Application

System configuration

For the analysis of Beta-Cyclodextrin we selected a Flexcell with gold working electrode. This cell has an exchangeable working electrode which is particularly useful in pulsed electrochemical detection. The electrode material tends to vanish over the years, in the process. Exchanging an electrode disc only takes a few minutes. The HyREF is completely maintenance free even at pH 13! The ALEXYS system comprises the following parts:

  • AS 110 autosampler, cool
  • LC 110S HPLC pump (2)
  • OR 110 organiser
  • Clarity data acquisition software
  • DECADE Elite electrochemical detector
  • Flexcell with Au WE, HyREF

ALEXYS with DECADE Elite

This system includes Helium-proof solvent bottles. 

Part no Description
180.0055E ALEXYS HPAEC-PAD Analyzer, HP gradient
250.1086
IonPac AG11 guard column, 50 x 4.0 mm ID
250.1087 IonPac AS11 analytical column, 250 x 4.0 mm ID