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En utilisant le syst\u00e8me ROXY\u2122 Exceed d’Antec Scientific, qui fonctionne avec chaque MS pour r\u00e9aliser une \u00e9lectrochimie-MS (EC-MS) en ligne, les \u00e9tudes du m\u00e9tabolisme des m\u00e9dicaments\/x\u00e9nobiotiques peuvent \u00eatre compl\u00e9t\u00e9es et consid\u00e9rablement acc\u00e9l\u00e9r\u00e9es<\/strong>.<\/p>\n L’EC-MS a \u00e9t\u00e9 appliqu\u00e9e avec succ\u00e8s pour la pr\u00e9diction rapide et la simulation du m\u00e9tabolisme oxydatif des m\u00e9dicaments (\u00ab\u00a0in-electro\u00a0\u00bb par opposition \u00e0 in-vivo ou in- vitro). Les m\u00e9tabolites sont form\u00e9s instantan\u00e9ment dans la cellule \u00e9lectrochimique (oxydation biomim\u00e9tique), imitant la biotransformation enzymatique des r\u00e9actions du cytochrome P450 du foie (r\u00e9action de phase I), y compris la formation d’adduits (r\u00e9actions de phase II). Par rapport aux m\u00e9thodes conventionnelles in-vivo<\/em> (par exemple, rongeurs, humains) ou in-vitro<\/em> (par exemple, microsomes), des \u00e9conomies consid\u00e9rables de temps et de co\u00fbts ont \u00e9t\u00e9 prouv\u00e9es.<\/p>\n Lire la suite :<\/strong><\/p>\n [\/et_pb_text][\/et_pb_column][et_pb_column type=\u00a0\u00bb1_3″ _builder_version=\u00a0\u00bb4.16″ custom_padding=\u00a0\u00bb5%|5%|||false|false\u00a0\u00bb global_colors_info=\u00a0\u00bb{}\u00a0\u00bb custom_padding__hover=\u00a0\u00bb|||\u00a0\u00bb][et_pb_image src=\u00a0\u00bbhttps:\/\/antecscientific.com\/wp-content\/uploads\/2020\/12\/drug_development_funnel.png\u00a0\u00bb title_text=\u00a0\u00bbtunnel_de_d\u00e9veloppement_de_m\u00e9dicaments\u00a0\u00bb _builder_version=\u00a0\u00bb4.16″ _module_preset=\u00a0\u00bbdefault\u00a0\u00bb global_colors_info=\u00a0\u00bb{}\u00a0\u00bb][\/et_pb_image][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>\n","protected":false},"excerpt":{"rendered":" M\u00e9tabolisme des m\u00e9dicaments\/X\u00e9nobiotiques Pr\u00e9dire jusqu’\u00e0 80 % de tous les m\u00e9tabolites d’un m\u00e9dicament en quelques minutes D\u00e9couvrez des m\u00e9tabolites non d\u00e9tect\u00e9s par les exp\u00e9riences in-vivo et in-vitro. Acc\u00e8s aux m\u00e9tabolites et interm\u00e9diaires r\u00e9actifs de courte dur\u00e9e de vie R\u00e9actions de phase I et II en quelques minutes sans interactions biologiques Aper\u00e7u complet de la voie […]<\/p>\n","protected":false},"author":3,"featured_media":0,"parent":16795,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"class_list":["post-17952","page","type-page","status-publish","hentry"],"yoast_head":"\n\n