{"id":16839,"date":"2020-08-30T12:59:55","date_gmt":"2020-08-30T10:59:55","guid":{"rendered":"https:\/\/antecscientific.com\/neurotransmetteurs\/"},"modified":"2025-09-09T12:44:01","modified_gmt":"2025-09-09T10:44:01","slug":"neurotransmetteurs","status":"publish","type":"page","link":"https:\/\/antecscientific.com\/fr\/applications\/neurotransmetteurs\/","title":{"rendered":"Neurotransmetteurs"},"content":{"rendered":"

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Analyse des neurotransmetteurs<\/h2>\n

[\/et_pb_text][et_pb_text admin_label=\u00a0\u00bbParagraph\u00a0\u00bb _builder_version=\u00a0\u00bb4.16″ text_font=\u00a0\u00bb||||||||\u00a0\u00bb text_font_size=\u00a0\u00bb18px\u00a0\u00bb text_line_height=\u00a0\u00bb2em\u00a0\u00bb header_font=\u00a0\u00bb||||||||\u00a0\u00bb header_2_font=\u00a0\u00bbRaleway|700|||||||\u00a0\u00bb header_2_font_size=\u00a0\u00bb50px\u00a0\u00bb header_2_line_height=\u00a0\u00bb1.4em\u00a0\u00bb header_6_font=\u00a0\u00bbRaleway|700||on|||||\u00a0\u00bb header_6_font_size=\u00a0\u00bb16px\u00a0\u00bb header_6_letter_spacing=\u00a0\u00bb5px\u00a0\u00bb header_6_line_height=\u00a0\u00bb1.8em\u00a0\u00bb text_orientation=\u00a0\u00bbjustified\u00a0\u00bb max_width=\u00a0\u00bb700px\u00a0\u00bb module_alignment=\u00a0\u00bbcenter\u00a0\u00bb custom_margin=\u00a0\u00bb0px||||false|false\u00a0\u00bb custom_padding=\u00a0\u00bb0px||||false|false\u00a0\u00bb header_2_font_size_tablet=\u00a0\u00bb35px\u00a0\u00bb header_2_font_size_phone=\u00a0\u00bb25px\u00a0\u00bb header_2_font_size_last_edited=\u00a0\u00bbon|phone\u00a0\u00bb text_orientation_tablet=\u00a0\u00bb\u00a0\u00bb text_orientation_phone=\u00a0\u00bbleft\u00a0\u00bb text_orientation_last_edited=\u00a0\u00bbon|desktop\u00a0\u00bb global_colors_info=\u00a0\u00bb{}\u00a0\u00bb]L’analyseur de neurotransmetteurs ALEXYS<\/a> a \u00e9t\u00e9 mis au point pour l’analyse d’\u00e9chantillons de tissu c\u00e9r\u00e9bral, de mouche \u00e0 fruits ou de microdialyse. Nos notes d’application d\u00e9crivent les d\u00e9fis auxquels nous avons \u00e9t\u00e9 confront\u00e9s et nos publications prouvent que nous avons fait nos preuves. L’ALEXYS est bas\u00e9 sur une UHPLC avec d\u00e9tection \u00e9lectrochimique et pr\u00e9sente quelques caract\u00e9ristiques uniques qui le rendent adapt\u00e9 \u00e0 la recherche en neurosciences. Le processus de d\u00e9veloppement a consist\u00e9 \u00e0 \u00e9liminer les goulets d’\u00e9tranglement et \u00e0 am\u00e9liorer les performances du syst\u00e8me jusqu’\u00e0 ce qu’elles atteignent leur niveau actuel.
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Petit volume d’\u00e9chantillon<\/h2>\n

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Sensibilit\u00e9<\/h2>\n

[\/et_pb_text][et_pb_text admin_label=\u00a0\u00bbParagraph\u00a0\u00bb _builder_version=\u00a0\u00bb4.16″ text_font=\u00a0\u00bb||||||||\u00a0\u00bb text_font_size=\u00a0\u00bb18px\u00a0\u00bb text_line_height=\u00a0\u00bb2em\u00a0\u00bb header_font=\u00a0\u00bb||||||||\u00a0\u00bb header_2_font=\u00a0\u00bbRaleway|700|||||||\u00a0\u00bb header_2_font_size=\u00a0\u00bb50px\u00a0\u00bb header_2_line_height=\u00a0\u00bb1.4em\u00a0\u00bb header_6_font=\u00a0\u00bbRaleway|700||on|||||\u00a0\u00bb header_6_font_size=\u00a0\u00bb16px\u00a0\u00bb header_6_letter_spacing=\u00a0\u00bb5px\u00a0\u00bb header_6_line_height=\u00a0\u00bb1.8em\u00a0\u00bb text_orientation=\u00a0\u00bbjustified\u00a0\u00bb max_width=\u00a0\u00bb700px\u00a0\u00bb module_alignment=\u00a0\u00bbcenter\u00a0\u00bb custom_margin=\u00a0\u00bb0px||||false|false\u00a0\u00bb custom_padding=\u00a0\u00bb0px||||false|false\u00a0\u00bb header_2_font_size_tablet=\u00a0\u00bb35px\u00a0\u00bb header_2_font_size_phone=\u00a0\u00bb25px\u00a0\u00bb header_2_font_size_last_edited=\u00a0\u00bbon|phone\u00a0\u00bb text_orientation_tablet=\u00a0\u00bb\u00a0\u00bb text_orientation_phone=\u00a0\u00bbleft\u00a0\u00bb text_orientation_last_edited=\u00a0\u00bbon|desktop\u00a0\u00bb global_colors_info=\u00a0\u00bb{}\u00a0\u00bb]Deuxi\u00e8mement, le syst\u00e8me doit avoir une excellente sensibilit\u00e9<\/strong> pour pouvoir quantifier des concentrations extr\u00eamement faibles de certains neurotransmetteurs. L’ALEXYS utilise une cellule d’\u00e9coulement de type wall jet \u00e0 espacement r\u00e9glable, la SenCell. Des limites de d\u00e9tection allant jusqu’\u00e0 20 pmol\/L pour la dopamine, la s\u00e9rotonine et la noradr\u00e9naline ont \u00e9t\u00e9 rapport\u00e9es (0,1 fmole). Pour l’ac\u00e9tylcholine, une \u00e9tape interm\u00e9diaire avec un r\u00e9acteur enzymatique post-colonne est n\u00e9cessaire, et une limite de d\u00e9tection d’environ 1 nmol\/L peut \u00eatre obtenue.
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S\u00e9paration<\/h2>\n

[\/et_pb_text][et_pb_text admin_label=\u00a0\u00bbParagraph\u00a0\u00bb _builder_version=\u00a0\u00bb4.16″ text_font=\u00a0\u00bb||||||||\u00a0\u00bb text_font_size=\u00a0\u00bb18px\u00a0\u00bb text_line_height=\u00a0\u00bb2em\u00a0\u00bb header_font=\u00a0\u00bb||||||||\u00a0\u00bb header_2_font=\u00a0\u00bbRaleway|700|||||||\u00a0\u00bb header_2_font_size=\u00a0\u00bb50px\u00a0\u00bb header_2_line_height=\u00a0\u00bb1.4em\u00a0\u00bb header_6_font=\u00a0\u00bbRaleway|700||on|||||\u00a0\u00bb header_6_font_size=\u00a0\u00bb16px\u00a0\u00bb header_6_letter_spacing=\u00a0\u00bb5px\u00a0\u00bb header_6_line_height=\u00a0\u00bb1.8em\u00a0\u00bb text_orientation=\u00a0\u00bbjustified\u00a0\u00bb max_width=\u00a0\u00bb700px\u00a0\u00bb module_alignment=\u00a0\u00bbcenter\u00a0\u00bb custom_margin=\u00a0\u00bb0px||||false|false\u00a0\u00bb custom_padding=\u00a0\u00bb0px||||false|false\u00a0\u00bb header_2_font_size_tablet=\u00a0\u00bb35px\u00a0\u00bb header_2_font_size_phone=\u00a0\u00bb25px\u00a0\u00bb header_2_font_size_last_edited=\u00a0\u00bbon|phone\u00a0\u00bb text_orientation_tablet=\u00a0\u00bb\u00a0\u00bb text_orientation_phone=\u00a0\u00bbleft\u00a0\u00bb text_orientation_last_edited=\u00a0\u00bbon|desktop\u00a0\u00bb global_colors_info=\u00a0\u00bb{}\u00a0\u00bb]Troisi\u00e8mement, dans les \u00e9chantillons r\u00e9els, la sensibilit\u00e9 de<\/em> d\u00e9tection n’est pas la seule chose qui compte, lorsqu’il s’agit de la plus faible concentration d\u00e9tectable. La s\u00e9lectivit\u00e9<\/strong> ou la s\u00e9paration<\/strong> des neurotransmetteurs pertinents des autres composants de l’\u00e9chantillon est \u00e9galement importante. Par cons\u00e9quent, des colonnes UHPLC \u00e0 haute performance ont \u00e9t\u00e9 s\u00e9lectionn\u00e9es pour la s\u00e9paration. Des rendements de s\u00e9paration (nombre de plaques) de 200 000 \/m se sont av\u00e9r\u00e9s r\u00e9alisables.
\n[\/et_pb_text][\/et_pb_column][et_pb_column type=\u00a0\u00bb1_3″ _builder_version=\u00a0\u00bb4.16″ custom_padding=\u00a0\u00bb5%|5%|||false|false\u00a0\u00bb global_colors_info=\u00a0\u00bb{}\u00a0\u00bb custom_padding__hover=\u00a0\u00bb|||\u00a0\u00bb][\/et_pb_column][\/et_pb_row][et_pb_row custom_padding_last_edited=\u00a0\u00bbon|phone\u00a0\u00bb admin_label=\u00a0\u00bbDividerline\u00a0\u00bb _builder_version=\u00a0\u00bb4.16″ width=\u00a0\u00bbauto\u00a0\u00bb max_width=\u00a0\u00bbnone\u00a0\u00bb custom_padding=\u00a0\u00bb|0px|||false|false\u00a0\u00bb custom_padding_tablet=\u00a0\u00bb\u00a0\u00bb custom_padding_phone=\u00a0\u00bb|10%|||false|false\u00a0\u00bb locked=\u00a0\u00bboff\u00a0\u00bb collapsed=\u00a0\u00bbon\u00a0\u00bb global_colors_info=\u00a0\u00bb{}\u00a0\u00bb][et_pb_column type=\u00a0\u00bb4_4″ _builder_version=\u00a0\u00bb4.16″ global_colors_info=\u00a0\u00bb{}\u00a0\u00bb][et_pb_divider color=\u00a0\u00bb#dee1e6″ _builder_version=\u00a0\u00bb4.16″ global_colors_info=\u00a0\u00bb{}\u00a0\u00bb][\/et_pb_divider][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=\u00a0\u00bb2_3,1_3″ custom_padding_last_edited=\u00a0\u00bbon|phone\u00a0\u00bb _builder_version=\u00a0\u00bb4.16″ width=\u00a0\u00bbauto\u00a0\u00bb max_width=\u00a0\u00bbnone\u00a0\u00bb custom_padding=\u00a0\u00bb27px|0|27px|0px|false|false\u00a0\u00bb custom_padding_tablet=\u00a0\u00bb|0px||0px||true\u00a0\u00bb custom_padding_phone=\u00a0\u00bb|10%||0px|false|false\u00a0\u00bb global_colors_info=\u00a0\u00bb{}\u00a0\u00bb][et_pb_column type=\u00a0\u00bb2_3″ _builder_version=\u00a0\u00bb4.16″ custom_padding=\u00a0\u00bb|||\u00a0\u00bb global_colors_info=\u00a0\u00bb{}\u00a0\u00bb custom_padding__hover=\u00a0\u00bb|||\u00a0\u00bb][et_pb_text admin_label=\u00a0\u00bbSubtitle\u00a0\u00bb _builder_version=\u00a0\u00bb4.16″ text_font=\u00a0\u00bb||||||||\u00a0\u00bb text_line_height=\u00a0\u00bb2em\u00a0\u00bb header_font=\u00a0\u00bb||||||||\u00a0\u00bb header_2_font=\u00a0\u00bb|600||on|||||\u00a0\u00bb header_2_text_color=\u00a0\u00bb#df0834″ header_2_font_size=\u00a0\u00bb20px\u00a0\u00bb header_2_line_height=\u00a0\u00bb1.4em\u00a0\u00bb header_6_font=\u00a0\u00bb|700||on|||||\u00a0\u00bb header_6_font_size=\u00a0\u00bb16px\u00a0\u00bb header_6_letter_spacing=\u00a0\u00bb5px\u00a0\u00bb header_6_line_height=\u00a0\u00bb1.8em\u00a0\u00bb max_width=\u00a0\u00bb700px\u00a0\u00bb module_alignment=\u00a0\u00bbcenter\u00a0\u00bb custom_margin=\u00a0\u00bb||0px||false|false\u00a0\u00bb custom_padding=\u00a0\u00bb||0px||false|false\u00a0\u00bb header_2_font_size_tablet=\u00a0\u00bb25px\u00a0\u00bb header_2_font_size_phone=\u00a0\u00bb25px\u00a0\u00bb header_2_font_size_last_edited=\u00a0\u00bbon|phone\u00a0\u00bb global_colors_info=\u00a0\u00bb{}\u00a0\u00bb]<\/p>\n

Deuxi\u00e8me canal<\/h2>\n

[\/et_pb_text][et_pb_text admin_label=\u00a0\u00bbParagraph\u00a0\u00bb _builder_version=\u00a0\u00bb4.16″ text_font=\u00a0\u00bb||||||||\u00a0\u00bb text_font_size=\u00a0\u00bb18px\u00a0\u00bb text_line_height=\u00a0\u00bb2em\u00a0\u00bb header_font=\u00a0\u00bb||||||||\u00a0\u00bb header_2_font=\u00a0\u00bbRaleway|700|||||||\u00a0\u00bb header_2_font_size=\u00a0\u00bb50px\u00a0\u00bb header_2_line_height=\u00a0\u00bb1.4em\u00a0\u00bb header_6_font=\u00a0\u00bbRaleway|700||on|||||\u00a0\u00bb header_6_font_size=\u00a0\u00bb16px\u00a0\u00bb header_6_letter_spacing=\u00a0\u00bb5px\u00a0\u00bb header_6_line_height=\u00a0\u00bb1.8em\u00a0\u00bb text_orientation=\u00a0\u00bbjustified\u00a0\u00bb max_width=\u00a0\u00bb700px\u00a0\u00bb module_alignment=\u00a0\u00bbcenter\u00a0\u00bb custom_margin=\u00a0\u00bb0px||||false|false\u00a0\u00bb custom_padding=\u00a0\u00bb0px||||false|false\u00a0\u00bb header_2_font_size_tablet=\u00a0\u00bb35px\u00a0\u00bb header_2_font_size_phone=\u00a0\u00bb25px\u00a0\u00bb header_2_font_size_last_edited=\u00a0\u00bbon|phone\u00a0\u00bb text_orientation_tablet=\u00a0\u00bb\u00a0\u00bb text_orientation_phone=\u00a0\u00bbleft\u00a0\u00bb text_orientation_last_edited=\u00a0\u00bbon|desktop\u00a0\u00bb global_colors_info=\u00a0\u00bb{}\u00a0\u00bb]Il existe n\u00e9anmoins des cas difficiles avec des pics co-\u00e9lu\u00e9s, ou lorsque des concentrations \u00e9lev\u00e9es et extr\u00eamement faibles de substances sont \u00e9lu\u00e9es de mani\u00e8re tr\u00e8s proche. Une deuxi\u00e8me voie<\/strong> ou configuration \u00e0 double voie (DCC) a \u00e9t\u00e9 d\u00e9velopp\u00e9e, avec deux m\u00e9thodes HPLC individuelles utilisant le m\u00eame injecteur d’\u00e9chantillon avec deux boucles d’injection. Le m\u00eame \u00e9chantillon peut \u00eatre analys\u00e9 simultan\u00e9ment dans deux conditions HPLC totalement diff\u00e9rentes. Lors de l’analyse des neurotransmetteurs monoamines, y compris les m\u00e9tabolites acides que sont l’acide homovanillique (HVA), l’acide 5-hydroxyindole ac\u00e9tique (5-HIAA) et l’acide 3,4-dihydroxyph\u00e9nylac\u00e9tique (DOPAC), on obtient une excellente s\u00e9paration et quantification de toutes les substances pertinentes dans des conditions de pH acide (canal 1) et neutre (canal 2).
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Temps d’analyse court<\/h2>\n

[\/et_pb_text][et_pb_text admin_label=\u00a0\u00bbParagraph\u00a0\u00bb _builder_version=\u00a0\u00bb4.16″ text_font=\u00a0\u00bb||||||||\u00a0\u00bb text_font_size=\u00a0\u00bb18px\u00a0\u00bb text_line_height=\u00a0\u00bb2em\u00a0\u00bb header_font=\u00a0\u00bb||||||||\u00a0\u00bb header_2_font=\u00a0\u00bbRaleway|700|||||||\u00a0\u00bb header_2_font_size=\u00a0\u00bb50px\u00a0\u00bb header_2_line_height=\u00a0\u00bb1.4em\u00a0\u00bb header_6_font=\u00a0\u00bbRaleway|700||on|||||\u00a0\u00bb header_6_font_size=\u00a0\u00bb16px\u00a0\u00bb header_6_letter_spacing=\u00a0\u00bb5px\u00a0\u00bb header_6_line_height=\u00a0\u00bb1.8em\u00a0\u00bb text_orientation=\u00a0\u00bbjustified\u00a0\u00bb max_width=\u00a0\u00bb700px\u00a0\u00bb module_alignment=\u00a0\u00bbcenter\u00a0\u00bb custom_margin=\u00a0\u00bb0px||||false|false\u00a0\u00bb custom_padding=\u00a0\u00bb0px||||false|false\u00a0\u00bb header_2_font_size_tablet=\u00a0\u00bb35px\u00a0\u00bb header_2_font_size_phone=\u00a0\u00bb25px\u00a0\u00bb header_2_font_size_last_edited=\u00a0\u00bbon|phone\u00a0\u00bb text_orientation_tablet=\u00a0\u00bb\u00a0\u00bb text_orientation_phone=\u00a0\u00bbleft\u00a0\u00bb text_orientation_last_edited=\u00a0\u00bbon|desktop\u00a0\u00bb global_colors_info=\u00a0\u00bb{}\u00a0\u00bb]La quatri\u00e8me exigence – un souhait dans de nombreux cas – est un temps d’analyse court<\/strong> ou la rapidit\u00e9 de l’analyse<\/strong>. L’introduction des colonnes et des instruments UHPLC a chang\u00e9 la donne \u00e0 cet \u00e9gard. Un temps d’analyse de moins de 2 minutes pour la dopamine et la s\u00e9rotonine dans les \u00e9chantillons de dialyse est maintenant consid\u00e9r\u00e9 comme \u00ab\u00a0normal\u00a0\u00bb. L’analyse du GABA et du glutamate utilise une \u00e9tape de d\u00e9rivatisation enti\u00e8rement automatis\u00e9e. En d\u00e9veloppant une m\u00e9thode avec un lavage de la colonne pour se d\u00e9barrasser des interf\u00e9rences \u00e0 \u00e9lution tardive, le temps total d’ex\u00e9cution a \u00e9t\u00e9 consid\u00e9rablement r\u00e9duit.
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R\u00e9sum\u00e9<\/h2>\n

[\/et_pb_text][et_pb_text admin_label=\u00a0\u00bbParagraph\u00a0\u00bb _builder_version=\u00a0\u00bb4.16″ text_font=\u00a0\u00bb||||||||\u00a0\u00bb text_font_size=\u00a0\u00bb18px\u00a0\u00bb text_line_height=\u00a0\u00bb2em\u00a0\u00bb header_font=\u00a0\u00bb||||||||\u00a0\u00bb header_2_font=\u00a0\u00bbRaleway|700|||||||\u00a0\u00bb header_2_font_size=\u00a0\u00bb50px\u00a0\u00bb header_2_line_height=\u00a0\u00bb1.4em\u00a0\u00bb header_6_font=\u00a0\u00bbRaleway|700||on|||||\u00a0\u00bb header_6_font_size=\u00a0\u00bb16px\u00a0\u00bb header_6_letter_spacing=\u00a0\u00bb5px\u00a0\u00bb header_6_line_height=\u00a0\u00bb1.8em\u00a0\u00bb text_orientation=\u00a0\u00bbjustified\u00a0\u00bb max_width=\u00a0\u00bb700px\u00a0\u00bb module_alignment=\u00a0\u00bbcenter\u00a0\u00bb custom_margin=\u00a0\u00bb0px||||false|false\u00a0\u00bb custom_padding=\u00a0\u00bb0px||||false|false\u00a0\u00bb header_2_font_size_tablet=\u00a0\u00bb35px\u00a0\u00bb header_2_font_size_phone=\u00a0\u00bb25px\u00a0\u00bb header_2_font_size_last_edited=\u00a0\u00bbon|phone\u00a0\u00bb text_orientation_tablet=\u00a0\u00bb\u00a0\u00bb text_orientation_phone=\u00a0\u00bbleft\u00a0\u00bb text_orientation_last_edited=\u00a0\u00bbon|desktop\u00a0\u00bb global_colors_info=\u00a0\u00bb{}\u00a0\u00bb]Un certain nombre de m\u00e9thodes ont \u00e9t\u00e9 d\u00e9velopp\u00e9es pour illustrer la polyvalence du syst\u00e8me ALEXYS. Les m\u00e9thodes relatives \u00e0 la 3-hydroxykynur\u00e9nine (3-HK) et aux neurotransmetteurs de la mouche du vinaigre (octopamine, tyrosine, tryptophane et tyramine) sont bas\u00e9es sur les m\u00e9thodes relatives aux monoamines. L’analyse de plusieurs grands acides amin\u00e9s neutres (LNAA – pr\u00e9curseurs de divers neurotransmetteurs c\u00e9r\u00e9braux) a \u00e9t\u00e9 r\u00e9alis\u00e9e \u00e0 l’aide de la proc\u00e9dure automatis\u00e9e OPA, comme pour le GABA et le glutamate. Les aminothiols et le glutathion jouent un r\u00f4le important dans le d\u00e9veloppement de la sant\u00e9. r\u00f4le dans la d\u00e9fense antioxydante du cerveau et les maladies neurod\u00e9g\u00e9n\u00e9ratives. Ils sont analys\u00e9s \u00e0 l’aide de l’ALEXYS avec une cellule \u00e0 flux avec une \u00e9lectrode en diamant dop\u00e9 au bore. Les notes d’application peuvent \u00eatre t\u00e9l\u00e9charg\u00e9es gratuitement.<\/span>
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Autres pages de demande :<\/h2>\n

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